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TacrolimusCAS: 104987-11-3

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Quick Details
Synonyms: 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-;FK-506;FK506;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine- 1,7,20,21(4H,23H)-tetrone,5,6,8,11,- 12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro- 5,19-dihydroxy-3-[(1E)-2- [(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylethenyl]-14,16-dimethoxy-4,10,12,18- tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,- 9E,12S,14S,15R,16S,18R,19R,26aS)-;FR 900506;Prograf;dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-;FK 506;Fujimycin;FR-900506;[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-;Tacrolimus (FK506);Tacrolimus(FK-506);Tacrolimus(FK506);Tacrolimus, FK-506;Taccrolimus;Tacrolimus [GMP];15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,;Prograde metamorphismPrograf; Classification: Pharmaceutical
EINECS: Molecular Formula: C44H69NO12
Melting Point: 113-115°C Boiling Point: 871.7 °C at 760 mmHg
Stability: Water Solubility: DMSO: >3 mg/mL
Refractive index: 1.549 Flash Point: 481 °C
Purity: 99%min Appearance: White crystalline powder
HazardClass: Brand Name: Aopharm
Packaging & Delivery
Packaging Detail: 100G/500G/1KG/2KG/5KG
Delivery Detail: By courier/Sea/Air
Detailed Description
[Company Profile]
Company Name: Shijiazhuang Aopharm Import & Export Trading Co.,Ltd
Main products: Pharmaceutical inermediates & raw materials, pharmaceutical preparations, Dyes & Pigments, Fince chemicals, Custom synthesis.
Assay (on dry basis, HPLC) Not less than 99%
Water (K.F.)                                 Not more than 3.0%
Specific Rotation                         Between -75.00 ~ -90.00
Heavy metals                         Not more than 10PPM
Residue on ignition                 Not more than 0.1%
Related substances                 Not more than 2.0%
Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug that is used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2 mediated diseases such as Kimura's disease and the skin condition vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production by T-cells.

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